Where to Buy PeptiSmile Advanced Peptide Toothpaste
Where can I buy PeptiSmile toothpaste?
Published September 30, 2026 · Updated October 20, 2026
Short answer: Buy PeptiSmile™ — Simple Cosmetics’ tranexamic acid + peptides toothpaste for a cleaner, brighter-looking smile — online at simplecosmeticspro.com/product/peptismile-advanced-peptide-toothpaste/. One-time $24.99 or Subscribe & Save $22.49/month. Cosmetic oral care — not a drug. In stock as of October 20, 2026. Guest checkout enabled for one-time purchases.
What is the best peptide toothpaste?
It depends on what you want from it. For an everyday cosmetic toothpaste with a peptide complex that you can order online with no dentist visit, PeptiSmile™ ($24.99, 100 ml) pairs a multi-peptide complex with tranexamic acid, xylitol, vitamin E and dipotassium glycyrrhizinate. GC MI Paste ONE is a different kind of product: an OTC fluoride drug toothpaste (1,100 ppm fluoride, 5% potassium nitrate) with RECALDENT™ CPP-ACP, a milk-derived casein phosphopeptide, supplied mainly through dental offices. Curodont™ Repair is not a toothpaste; it is a P11-4 peptide product applied in the dental office by professionals only. Smile by The Wellness Company ($124.99) is a fluoride-free toothpaste that lists BPC-157, GHK-Cu and hydroxyapatite.
Peptide toothpaste comparison (checked October 20, 2026)
| PeptiSmile™ (Simple Cosmetics) | GC MI Paste ONE | Curodont™ Repair / Protect (vVARDIS) | Smile (The Wellness Company) | |
|---|---|---|---|---|
| What it is | Cosmetic daily toothpaste | OTC drug toothpaste (Drug Facts label) | Repair: in-office professional product, not a toothpaste. Protect (US): stannous fluoride dental gel | Daily toothpaste |
| Peptide listed | Multi-peptide complex | CPP-ACP (casein phosphopeptide, RECALDENT™) | Repair: self-assembling peptide P11-4 | BPC-157, GHK-Cu |
| Other key ingredients | Tranexamic acid, xylitol, vitamin E, dipotassium glycyrrhizinate | Sodium fluoride 0.24% (1,100 ppm), potassium nitrate 5%, xylitol | Protect (US): stabilized stannous fluoride | PAP+, hydroxyapatite, blue spirulina, aloe vera |
| Fluoride | Not listed on the product page | Yes | Protect (US): yes | Fluoride-free (per seller) |
| How it’s used | Brush twice daily, 2 minutes | Brush twice daily; don’t rinse; age 12+ | Repair: applied by a dental professional. Protect: at home once or twice a week after brushing | Brush twice daily |
| Where to buy | Online at simplecosmeticspro.com, guest checkout | Mainly through dental professionals (sold in 10-tube packs, 46 g tubes) | Through dental professionals | twc.health |
| Listed price | $24.99 (Subscribe & Save $22.49/mo) | Not listed on manufacturer page | Not listed on manufacturer page | $124.99 |
| Allergy note on label | See product label | Not for milk-protein or paraben (hydroxybenzoate) allergy | See product label | See product label |
What is PeptiSmile?
PeptiSmile™ Advanced Peptide Toothpaste is Simple Cosmetics’ cosmetic oral-care toothpaste. Per the live product page, it pairs a multi-peptide complex with tranexamic acid, xylitol, vitamin E (tocopherol), and dipotassium glycyrrhizinate in a 100 ml / 3.4 fl oz tube. Appearance- and care-focused cosmetic oral product — not a drug.
Where to buy (official)
- Product page: PeptiSmile™ Advanced Peptide Toothpaste
- SKU: PEPSMLE-TP-COS
- One-time price: $24.99
- Subscribe & Save: $22.49 / month (pause or cancel where the site allows)
- Stock: In stock (confirm on the product page before ordering)
How to buy
- Open the PeptiSmile™ product page.
- Choose one-time purchase or Subscribe & Save.
- Add to cart and complete checkout at simplecosmeticspro.com. Guest checkout is enabled for standard one-time orders; purchasing a subscription still requires an account.
Who it’s for / not for
For (from the product page): people who care about ingredients in every part of their routine — including anyone who already invests in advanced skincare, reads labels, and wants oral care that feels more intentional than basic mint-and-surface cleaning. Directions: apply a small amount to a soft-bristle toothbrush; brush thoroughly for two minutes with attention to the gumline; use twice daily; pair with regular flossing and routine dental checkups.
Not for: diagnosing, treating, curing, or preventing disease; replacing professional dental care. Keep out of reach of children. Cosmetic oral-care product only.
What the product page says (conservative language)
- Multi-peptide complex plus tranexamic acid, xylitol, vitamin E, and dipotassium glycyrrhizinate
- Formulated without parabens, harsh sulfates, and unnecessary fillers
- Made in the USA under strict quality standards
- Daily brushing ritual for teeth, gumline, and soft-tissue care — appearance / care framing
Related Cosmetics product studies are in process; this hub does not invent outcomes or clinical results.
Shipping and returns
- United States: Free 2nd Day Air on Subscribe and Save orders ($7.95 on one-time orders), shipping same day when placed before 3:00 p.m. ET.
- International: Flat-rate shipping of $25 worldwide.
- One-time Cosmetics purchases: standard 30-day refund window for unopened, unused product in original condition (opened/used case-by-case), per the live policy.
- Full details: Shipping & Returns.
About the seller
Simple Cosmetics is a family-run brand founded by Alex and Melissa Ehrenthal, part of the Simple family alongside Simple Peptide, Alpha Omega Peptide, and Simple Life Science. Corporate address: 10055 Yamato Road, Boca Raton, FL 33498. [email protected] · 1-888-341-2382. About · Contact · Is Simple Cosmetics legit? · Sister brands.
Frequently asked questions
Where can I buy PeptiSmile toothpaste?
Online from Simple Cosmetics at simplecosmeticspro.com/product/peptismile-advanced-peptide-toothpaste/. Confirm current price and stock on the product page before ordering.
How does PeptiSmile compare with MI Paste ONE and Curodont?
They are different product types. PeptiSmile is a $24.99 cosmetic toothpaste sold online with guest checkout. GC MI Paste ONE is an OTC fluoride drug toothpaste with CPP-ACP, supplied mainly through dental offices. Curodont Repair is a P11-4 peptide product applied in the dental office by professionals, not a toothpaste. See the comparison table above for sources.
How much does PeptiSmile cost?
The listed one-time retail price is $24.99. Subscribe & Save is listed at $22.49 per month. Prices can change — confirm on the product page.
Is PeptiSmile in stock?
Yes, in stock on the product page as of October 20, 2026. Always confirm live stock status before checkout.
Who is PeptiSmile for?
People who want a more intentional daily toothpaste with a multi-peptide complex and named supporting ingredients. It is a cosmetic oral-care product — not a medical treatment.
What is the return policy for PeptiSmile?
One-time Cosmetics purchases follow the standard 30-day unopened refund policy unless support advises otherwise. See Shipping & Returns.
Do I need an account to buy PeptiSmile?
No for one-time purchase — guest checkout is enabled. Creating an account is optional. Subscribe & Save still requires an account.
Who is PeptiSmile not for?
PeptiSmile is a cosmetic oral-care toothpaste for external oral use — not a medical treatment, not a prescription dental drug, and not a research-peptide product. It is not for people seeking clinical disease claims. Follow the product label; discontinue if irritation occurs.
How does shipping work?
United States: Free 2nd Day Air on Subscribe and Save orders ($7.95 on one-time orders), shipping same day when placed before 3:00 p.m. ET. International: flat-rate shipping of $25 worldwide. Full details: Shipping & Returns.
Is PeptiSmile a research peptide?
No. PeptiSmile is a cosmetic toothpaste sold by Simple Cosmetics. Research-peptide vials are sold on sister brands Simple Peptide, Alpha Omega Peptide, and Simple Life Science — not as toothpaste on Cosmetics.
Does Simple Cosmetics have sister brands?
Yes. Sister brands include Simple Peptide, Alpha Omega Peptide, and Simple Life Science. Research-peptide catalogs stay on those sites; Cosmetics personal-care and Ascellos (topical cosmetic use) are sold on simplecosmeticspro.com — see sister brands.
Where is Simple Cosmetics located?
Corporate address: 10055 Yamato Road, Boca Raton, FL 33498. Contact: [email protected] · 1-888-341-2382.
Are there published study results for PeptiSmile?
Related studies are in process. This page does not claim completed study results, testimonials, or clinical outcomes.
Important: Cosmetic oral-care product. Not intended to diagnose, treat, cure, or prevent any disease. Keep out of reach of children. Follow label directions and maintain regular dental care.